Inorganic Mass Spectrometry

Content
1. What is inorganic mass spectrometry?
2. Application of inorganic mass spectrometry
3. Inorganic mass spectrometry working principle
4. Features of inorganic mass spectrometer
5. Types of inorganic mass spectrometry
6. Inorganic mass spectrometry specifications
7. Inorganic mass spectrometer requirements for clean laboratory
8. How to maintain inorganic mass spectrometry?
9. Precautions for using inorganic mass spectrometry
10. How to order inorganic mass spectrometry?

Inorganic mass spectrometer is a mass spectrometer that ionizes the measured substance by inductively coupled high-frequency discharge or other means, mainly used for inorganic element trace analysis and isotope analysis, etc.

As a scientific analytical instrument, inorganic mass spectrometers are widely used in geology, mineralogy, geochemistry, nuclear industry, material science, environmental science, medical health, food chemistry, petrochemical industry, and other fields, as well as space technology and public security work and other special analysis.

The working principle of inorganic mass spectrometer is that the sample solution is formed into an aerosol by the nebulizer under the joint action of the peristaltic pump and nebulizer gas, and enters the fog chamber. After being selected by the fog chamber, the smaller diameter aerosol is desolvated, evaporated, atomized, and ionized in the plasma at a high temperature of about 6000-8000K, and most of them become positive ions with one charge, and the ions enter the vacuum system of the mass spectrometer under the action of the high-speed jet stream, after the sampling cone and separation cone.

Mass range
The range of atomic weights that can be measured by an inorganic mass spectrometer is the mass range of the mass spectrometer, with Da as its unit.
400000 Da is the mass range that the latest matrix-assisted laser desorption time-of-flight mass spectrometers can achieve.

Molecular ions
In inorganic mass spectrometry, when foreign electrons hit a molecule of an organic compound, most of them lose an electron, which makes a positive charge for the molecule, and molecular ions are such positively charged particles.
Molecular ions are used to determine the molecular weight of a compound.

Fragment ions
When the impacting electrons have high energy, which is higher than the energy required to ionize the molecule itself, a cleavage of part, most or all of the molecular ion occurs and the resulting molecular fragments can also be positively charged, which is called a fragment ion.
Fragment ions are used to determine the structure of compounds.

Features:
1. Floor standing inorganic mass spectrometer is equipped with an injection system that allows users to analyze a wide range of sample types with confidence
2. Simple design makes it easier to achieve easy maintenance.
3. Accurate control and stable performance.

Inorganic mass spectrometers are developing rapidly and are widely used for analytical testing in various fields. However, since many inorganic mass spectrometers test samples at ultra-trace levels or even lower, the environmental requirements are very high, requiring a very high level of cleanliness throughout the analytical process, so in some laboratories, it is necessary to customize a clean laboratory for the instrument.

The requirements of inorganic mass spectrometry for the laboratory
Maintain a very low inorganic blank.
Ensure that the instrument is not prone to malfunction due to its precision.

Laboratory basic structure
Inorganic mass spectrometer ultra-clean laboratory generally includes a dressing room, air shower room, pre-treatment room, balance room, instrument room, and auxiliary equipment room. Different rooms are not necessarily the same in terms of decoration, cleanliness, number of air changes, and temperature and humidity requirements.

Design basic requirements
To ensure the overall beauty of the laboratory, people-oriented, reasonable design.
The selected materials are required to be acid, alkali, and organic solvent resistant.
Clean room in line with clean laboratory construction specifications and related regulations to meet the needs of users.
Anti-static, no dust accumulation, durable, and easy to use and maintain.

Design basic requirements
To ensure the overall beauty of the laboratory, people-oriented, reasonable design.
The selected materials are required to be acid, alkali, and organic solvent resistant.
Clean room in line with the clean laboratory construction specifications and related regulations to meet the needs of users.
Anti-static, no dust accumulation, sturdy and durable for easy use and maintenance.

Air system
All lighting fixtures in the purification area use special ceiling purification lamps with waterproof and airtight characteristics. The illumination level in the laboratory is not less than 300 Lx. The laboratory has a professional control box and the power supply has a leakage detection alarm device. The professional electrical load is considered according to the instruments and supporting equipment. The shell of the electric equipment is reliably connected to the special grounding protection wire (PE), and the non-electric metal parts of all electric equipment are connected to the PE wire. The grounding required for mass spectrometers needs to be accounted for, with a resistance to ground of no larger than 1 ohm or 4 ohms.

Automatic control system
The automatic control system is the core of this clean laboratory, which will collect and control signals from air conditioning equipment such as hot and cold equipment, fresh air, air conditioning units, and other systems in the clean area to realize the automation of the clean area air conditioning equipment management system, which plays the role of centralized management, decentralized control, energy saving, and consumption reduction, and clean level assurance.
The use of communication, sensing, and computer technology to achieve process monitoring of clean air conditioning equipment, even unmanned operation of emerging control technology, the design of a complete structure, and advanced and open intelligent building monitoring system is the core of the building automation project. Each system is controlled by a set of PLC controllers, and eventually connected to a set of networks, connected to a color touch screen, and placed in the operating room, while various operations and displays of the system are completed on this interface, the control display interface controls the working status of various laboratory process equipment, coarse filter, medium-effect filter working status display of each system, various alarms of the air conditioning unit, system The control display interface controls the working status of various laboratory process equipment of each system, the working status display of coarse and medium efficiency filters, the various alarms of air conditioning units, the temperature and humidity display and control of the system, the automatic conversion of daytime and nighttime control modes, the linkage control of the exhaust and make-up air systems and various alarm functions.

Laboratory process equipment
Laboratory process equipment refers to the professional equipment that must be equipped in the laboratory in addition to experimental instruments for inorganic mass spectrometer services, mainly PP chemical safety cabinets, PP fume hoods, lab benches, water basin tables, reagent cabinets, lockers, shoe cabinets, emergency showers and other equipment, which is an important and indispensable part of the laboratory engineering construction.

Gas circuit system
Inorganic mass spectrometers require the professional design to ensure adequate and stable gas supply. Since the instrument is constantly working with gas, it is necessary to ensure that the gas circuit system with gas switch does not stop. Generally, the gas supply method adopts two levels of pressure reduction and 316LBA grade stainless steel piping. The gas source uses steel cylinders or liquid argon cylinders, preferably liquid argon cylinders.

Inorganic mass spectrometer is a major classification of a mass spectrometer, different from organic mass spectrometer is mainly inductively coupled high-frequency discharge to ionize the measured material mass spectrometer, mainly used for inorganic elements trace analysis and isotope analysis, etc., widely used. An inorganic mass spectrometer is a more sophisticated instrument, requiring regular maintenance to reduce failure.

Regular inorganic mass spectrometer mechanical pump vibration gas, once a week for ESI sources and once a day for APCI sources.
 
Check the condition of the inorganic mass spectrometer mechanical pump once a week.
 
Replace the inorganic mass spectrometer mechanical pump oil regularly, normally once in 125 days of continuous operation. When the pump oil is discolored or the liquid level drops below 1/2, it needs to be replaced immediately.
 
When there is clogging and sensitivity decreases, the inorganic mass spectrometer probe tip needs to be cleaned and the capillary tube needs to be replaced.
 
When the corona discharge needle (APCI) of the inorganic mass spectrometer looks corroded, darkened, or has decreased sensitivity it needs to be cleaned in time
 

When the sampling cone hole and baffle are dirty, black, or sensitivity loss timely cleaning, if the sensitivity is still low after cleaning the sampling cone hole, you need to clean the extraction cone hole, ion holder, and hexapolar device.

When disassembling the inorganic mass spectrometer, carefully remove the ion source and place it on a clean white cloth according to the protocol. Pay attention to electrostatic protection and put on clean special gloves. Use dust-free cloth or paper and dust-free rubber gloves. 2.

When cleaning the inorganic mass spectrometer, disassemble the ion source, place it in a beaker, add acetone, and ultrasonically clean it for 30-60 minutes, noting that some non-metallic parts cannot be ultrasonically cleaned with acetone. If the degree of pollution is heavy, can extend the ultrasonic time.

Polishing. After sonication, remove and dry at low temperature. Use special sanding paper to polish the oxidation part and serious pollution part carefully, the surface pollution and oxidation part can be polished clean, pay attention to polishing smooth, but do not excessively harm the metal surface.

When cleaning the inorganic mass spectrometer again, repeat step 2. Sometimes ultrasonic can also be used alternately with methanol and acetone, the effect may be better.

The general order is sanding first, then cleaning. Sanding is recommended to use more than 6000 mesh abrasive cloth, cleaning on the addition of solvent put in the ultrasound can be. Pay attention to the lens and other anti-scratch. 5.

Installation of inorganic mass spectrometer. Reassemble the dried ion source and install it back as it was.

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